Increased Cystic Fibrosis Severity And Deficiency In The Protein MBL2 Linked

Friday, February 22nd, 2008

Cystic fibrosis (CF), a hereditary disorder causing thick mucous production and frequent lung infections, is associated with a high mortality rate primarily due to lung failure. Although it is known that mutations in the CFTR gene cause the disease, variations in other genes between individuals with CF modify the severity ...

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Genetic Deficiency Of Glycogen Synthase Kinase-3Beta Corrects Diabetes In Mouse Models Of Insulin Resistance

Wednesday, February 20th, 2008

Diabetes is often characterized by a failure of insulin production by pancreatic Beta-cells to properly regulate glucose homeostasis. Insulin resistance can lead to ?-cell failure, and our studies have focused on elucidating the mechanisms involved in this postnatal failure. This week in the open-access journal PLoS Biology, Katsuya Tanabe, James Woodgett, ...

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