Archive for the ‘Prostate’ Category
Tuesday, February 26th, 2008
Oregon Health & Science University Cancer Institute researchers, in a first-of-its-kind study, have found that even men with advanced prostate cancer can take a much-needed safe break, or holiday, from chemotherapy.
The double-blind, randomized study, led by principal investigator Tomasz Beer, M.D., recently was published in the journal Cancer. Beer is ...
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Thursday, February 21st, 2008
Does exposure of baby boys -- in utero or in infancy -- to bisphenol A, a man-made chemical which mimics natural estrogens, predispose them to prostate cancer later in life?
A five-year, $2.6 million grant to a University of Illinois at Chicago researcher and her colleague aims to answer this question ...
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Monday, February 18th, 2008
Cougar Biotechnology, Inc. (NASDAQ:CGRB) announced that results from ongoing Phase I and Phase II clinical trials of Cougar's investigational drug, CB7630 (abiraterone acetate), were presented at the ASCO Genitourinary Cancers Symposium that is currently taking place in San Francisco, California. The data was presented today in both an oral presentation ...
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Monday, February 18th, 2008
UroToday.com - Dr. Nelson discussed that androgen-independent CaP progression is not really independent of androgens. Using microarray based expression profiling in LNCaP cells, gene expression following androgen deprivation therapy was performed. They sought to identify the regulatory cascade governing the progression to androgen-independence. This was correlated with human CaP tumor ...
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Monday, February 18th, 2008
UroToday.com - Dr. Oh reviewed the past and present of secondary hormonal therapies. He showed patient cases of sequential secondary therapies with outcomes supporting the heterogeneity of CaP. Some patients metastasize then develop castration resistant prostate cancer (CRPC) while others have CRPC when metastases occur, perhaps due to the increased ...
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Monday, February 18th, 2008
UroToday.com - John Isaacs, Johns Hopkins discussed stem cell biology. Cancer is caused by a series of genetic changes (both germ line and somatic). Genetic instability can occur even in cancer cells, influencing their behavior. He cited the Gleason scoring system as an example of phenotypic heterogeneity. The heterogeneity of ...
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Monday, February 18th, 2008
UroToday.com - Dr. Danila, spoke about abiraterone acetate (AA), an oral and irreversible inhibitor of CYP17 that decreases testosterone and DHT levels to undetectable. The study presented sought to determine the proportion of patients achieving a PSA decline of >50% and to assess toxicity. It was a multicenter trial using ...
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Monday, February 18th, 2008
UroToday.com - June Chan from UCSF presented on Nutritional Epidemiology of Prostate Cancer. In a population migration study, low-risk CaP populations moving to a high-risk area shifted to a higher risk profile. Chinese men in China had a CaP risk of 3/100,000, but after moving to the US this increased ...
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Sunday, February 17th, 2008
UroToday.com - Dr. Danila, spoke about abiraterone acetate (AA), an oral and irreversible inhibitor of CYP17 that decreases testosterone and DHT levels to undetectable. The study presented sought to determine the proportion of patients achieving a PSA decline of >50% and to assess toxicity. It was a multicenter trial using ...
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