Dartmouth Researchers Find That Arsenic Triggers Unique Mechanism In Rare Leukemia

Dartmouth Medical School (DMS) researchers have identified a new way that arsenite, a form of arsenic, acts in treating a rare cancer known as APL, or acute promyelocytic leukemia. Their study is published in the Jan. 3 issue of the Journal of the National Cancer Institute.

“We knew that arsenite was particularly effective against this cancer, and we wanted to figure out why,” says Sutisak Kitareewan, an author on this paper and an instructor of pharmacology and toxicology at DMS. “Now we know that arsenite destabilizes lysosomes, a part of a cell that contains certain enzymes, which, when released, often kill APL cells.”

APL is caused by the swapping of chromosomes 15 and 17, which forms a fusion protein. This fusion protein prevents certain blood cells from maturing and leads to an accumulation of immature leukemia cells. Researchers found that arsenite causes rapid destabilization of the lysosome in cells, and that breaks the lysosome apart, releasing enzymes that destroy these particular kinds of leukemia cells.

“We hope this finding will be used to inform further research into treating APL,” says co-author Ethan Dmitrovsky, professor of medicine and of pharmacology and toxicology, who is also affiliated with the Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center. “We also hope that further studies examine if this same mode of action is the basis for arsenic toxicity.”

About the Author

admin has written 6390 stories on this site.

Write a Comment

Gravatars are small images that can show your personality. You can get your gravatar for free today!

You must be logged in to post a comment.

Copyright © 2009 Medical News. All rights reserved.
Powered by WordPress.org, Custom Theme and ComFi.com Calling Card Company.
Close