New Edition Of Landmark Textbook Incorporates Contemporary Genome-Based View Of Biology

The third edition of a landmark genetics textbook–Recombinant DNA: Genes and Genomes–A Short Course–has just been released. Infused with descriptions of genome sequencing technologies, biological insights from sequencing projects, and practical applications of genetics and genomics research, the new edition of Recombinant DNA presents a modern, genome-centered view of biology.

In the book, Nobel laureate James D. Watson and Jan A. Witkowski join new coauthors Amy A. Caudy and Richard M. Myers to provide an authoritative yet accessible introduction to genetic and genomic research, methods, and applications. It is co-published by Cold Spring Harbor Laboratory Press and W.H. Freeman and Company.

“This volume presents what we think are the fundamental concepts of genetics and genomics that form the core of current molecular approaches to studying biological processes,” write the authors in the preface to the book. “They should be familiar to everyone who, in some way, needs to understand the background to what they may learn in a class on molecular genetics, consider when moving from another science to biology, or read a newspaper story covering some new discovery in biomedical research.”

The new edition of Recombinant DNA has had input from teaching faculty in many academic settings, and is designed for inquiry-based learning. It encourages students to think about the questions facing biologists in the laboratory, and consistently links fundamental concepts to the original experiments that have defined our understanding of DNA.

Written in a conversational style, the first 13 chapters provide a cohesive and comprehensive introduction to the fundamental concepts of genetics and genomics, as well as an inside look at the Human Genome Project, bioinformatic and experimental techniques for large-scale genomic and proteomic studies, a survey of the burgeoning epigenetics field, and RNA interference–the topic of the 2006 Nobel Prize for Physiology or Medicine.

The final three chapters highlight topics of general interest: identifying disease-causing genes, the genetic basis of cancer, and DNA fingerprinting and forensics. Examples of practical applications in human medicine are provided, and the future of human genetics and genomics projects are discussed.

“We hope that the topics selected and our treatment of them will make this book suitable for a wide range of readers: undergraduates and graduate students in topics directly related to those in this book–molecular, cell, and developmental biology; biochemistry; genetics; and biotechnology,” write the authors. “We also expect that others who wish to learn about the basics of molecular genetics and genomics will find the book useful, for example, medical students and physicians, forensic scientists, patent attorneys, and science journalists.”

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