Indiana University Pursues Dementia Research With Fourth NIH Center Grant
- Monday, January 1, 2007, 22:42
- Alzheimers / Dementia
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The exploration of dementia will continue at the Indiana University School of Medicine with the renewal of a National Institutes of Health grant for $7.3 million to fund the Indiana Alzheimer Disease Center. This is the fourth renewal of the original center grant which was awarded in 1991.
The NIH-funded Alzheimer disease centers are comprehensive programs that foster interdisciplinary research for the prevention, diagnosis and treatment of Alzheimer disease and other dementias. Health-care delivery and other support services for patients and their families are part of the centers’ focus.
There are 29 NIH-funded Alzheimer disease centers in the United States. Their role is to provide resources to enhance ongoing research, bringing together biomedical, behavioral and clinical investigators to study the cause, development, diagnosis, treatment and prevention of dementia.
IU Distinguished Professor Bernardino Ghetti, M.D., director of the Indiana Alzheimer Disease Center and professor of pathology, said much progress has been made in the field in the past 15 years. Highlights of the IADC’s accomplishments include:
- This summer, IADC scientists discovered two new mutations in the Progranulin gene. Recently, mutations in this gene were found to be associated with frontotemporal dementia, which is the leading cause of dementia after Alzheimer disease.
- A seminal contribution of IADC researchers was the discovery of a genetic mutation in the amyloid precursor protein gene associated with Alzheimer disease. Based on the discovery, an animal model was engineered by other scientists and has become the most widely used animal model for Alzheimer disease research.
- IADC researchers have made important contributions to the field of prion diseases, including the discovery of the neuropathologic and genetic basis of two hereditary disorders: Gerstmann-Sträussler-Scheinker disease and a prion protein cerebral amyloid angiopathy or PrP-CAA.
- One of the most significant contributions of IADC scientists stemmed from the study of a large family affected by a hereditary frontotemporal dementia. IADC researchers were part of the team that identified mutations in the Tau gene as the culprit. For this body of work, Dr. Ghetti was awarded the 1999 Potamkin Prize for Research in Pick’s, Alzheimer’s and Related Diseases by the American Academy of Neurology.
- IADC scientists have contributed to the body of knowledge of less known neurodegenerative dementias associated with mutations in the ferritin light polypeptide gene and neuroserpin gene. “The unified effort of the Indiana Alzheimer Disease Center has led to an increase in the understanding of forms of hereditary dementias,†said Dr. Ghetti. “These discoveries are essential to the development of treatment options for dementing illnesses, which could reach epidemic proportions as the baby boomer generation reaches old age.â€
For further information please go to:
Indiana Alzheimer Disease Center
Indiana University
Indiana University - Purdue University Indianapolis ![]()
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