Verapamil Versus Saline And Electromotive Drug Administration (EMDA) For Peyronie’s Disease: A Double-blind Placebo-control Trial
- Sunday, November 5, 2006, 15:14
- Urology / Nephrology
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UroToday.com - This abstract reported on a randomized placebo controlled trial of Verapamil versus Saline delivered by EMDA for Peyronie’s disease. This was a well-conducted trial of 42 men with PD who underwent EMDA using the Physion device from Italy, two times per week at 2.4 mA per treatment for three months.
In the Verapamil group, 65 %( mean 9 degrees) of subjects had measured improvement obtained by measuring maximum erection during duplex ultrasound versus 58% (mean 7 degrees) in the saline group. There were no adverse effects.
The investigators noted no significant difference in response between the two groups and introduced the concept of electrical current having its own potential therapeutic effect. They recommended the use of this modality for patients with mild deformity and pain. More studies were recommended.
Editor’s note:
There are no FDA approved medical therapies specifically for the management of Peyronie’s Disease. The solutions to the problem remain surgical. Because the natural history of Peyronie’s defines itself over 12-18 months, physicians and patients are left waiting to see whether the disease will stabilize, worsen or improve over that period of observation. Intralesional injection of drugs have been tried in the management of Peyronie’s since the 1950’s. Most recently Verapamil has shown favorable results when injected. This paper investigates the efficacy of EMDA as a non-invasive means of treating the plaque. EMDA is a simple outpatient treatment available in most physical therapy departments; medication is placed on a small patch applied to the skin directly over the plaque with electrical current generated by a unit that is about the size of an old transistor radio with a 9 volt battery the drug is driven into the tissues. With this contemporary technology it is possible to investigate a variety of drugs and avoid painful, repeated injections. Objectively these patients will need to be followed for relief of pain, softening of plaque, plaque size on ultrasound, penile curvature and erectile status.
JM Greenfield, SJ Shaw and LA Levine, Chicago, Illinois.
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